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The TP0969 Family [Function: Biogenesis / Secretion] Seed alignment | Full alignment

The spirochete bacterium Treponema pallidum ssp. pallidum is the etiological agent of syphilis, a chronic multistage disease. Using Electrospary Ionization Mass Spectrometry (ESI-MS/MS), TP0969 was identified as an outer membrane protein.Furthermore, TP0969 was predicted as an outer membrane ß barrel by CELLO, PSORT, HHomp and PRED-TMBB prediction algorithms and has a signal peptide based on Signal-CF and SignalP 4.1 prediction algorithms. TP0969 protein shows structural homology with TolC like protein.

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Literature references

Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry
PLoS Negl Trop Dis. 2016 Sep 8;10(9):e0004988. doi: 10.1371/journal.pntd.0004988. eCollection 2016 Sep.
PMID: 27606673

Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum
Infect Immun. 2010 Dec;78(12):5178-94. doi: 10.1128/IAI.00834-10. Epub 2010 Sep 27.
PMID: 20876295

PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
Bioinformatics. 2010 Jul 1;26(13):1608-15. doi: 10.1093/bioinformatics/btq249. Epub 2010 May 13.
PMID: 20472543

Prediction of protein subcellular localization
Proteins. 2006 Aug 15;64(3):643-51. doi: 10.1002/prot.21018.
PMID: 16752418

Elixir UTH dib compgen