Browse Text search Protein search Domain search Download User manual Related links Citation & Contact

The Cytohemolysin (CHL) Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | TC-DB page

Hemolysin, a heptameric porin, is secreted by Vibrio cholerae. The heptamer comprises a ring-like structure with an outer diameter of 135 Å. The channel pore consists of an upper large vestibule formed by ß prism and cytolysin domains, and the stem domains which form a 14-strand ß barrel.

Specify pHMMs' % coverageUnspecified More than   
Representative image:  fam_img

Literature references

Diversity of virulence-associated genes in pathogenic Aeromonas hydrophila isolates and their in vivo modulation at varied water temperatures
Microb Pathog. 2020 Oct;147:104424. doi: 10.1016/j.micpath.2020.104424. Epub 2020 Aug 6.
PMID: 32771658

Inhibition of interaction between Staphylococcus aureus ?-hemolysin and erythrocytes membrane by hydrolysable tannins: structure-related activity study
Sci Rep. 2020 Jul 7;10(1):11168. doi: 10.1038/s41598-020-68030-1.
PMID: 32636484

Development of a monoclonal antibody for specific detection of Vibrio parahaemolyticus and analysis of its antigen
J Microbiol Methods. 2020 Jun;173:105919. doi: 10.1016/j.mimet.2020.105919. Epub 2020 Apr 11.
PMID: 32289368

Occurrence and Abundance of Pathogenic Vibrio Species in Raw Oysters at Retail Seafood Markets in Northwestern Mexico
J Food Prot. 2019 Dec;82(12):2094-2099. doi: 10.4315/0362-028X.JFP-19-237.
PMID: 31724880

Induction of erythrocyte microvesicles by Escherichia Coli Alpha hemolysin
Biochem J. 2019 Nov 29;476(22):3455-3473. doi: 10.1042/BCJ20190546.
PMID: 31661116

Potential pathogenicity and antibiotic resistance of aquatic Vibrio isolates from freshwater in Slovakia
Folia Microbiol (Praha). 2020 Jun;65(3):545-555. doi: 10.1007/s12223-019-00760-w. Epub 2019 Nov 26.
PMID: 31773555

Molecular mechanisms of Vibrio parahaemolyticus pathogenesis
Microbiol Res. 2019 May;222:43-51. doi: 10.1016/j.micres.2019.03.003. Epub 2019 Mar 8.
PMID: 30928029

Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing
PLoS Pathog. 2018 Aug 23;14(8):e1007240. doi: 10.1371/journal.ppat.1007240. eCollection 2018 Aug.
PMID: 30138458

Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7385-90. doi: 10.1073/pnas.1017442108. Epub 2011 Apr 18.
PMID: 21502531

Elixir UTH dib compgen