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The Lysenin Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | TC-DB page

Lysenin is a PFT of Eisena fetida and a member of the aerolysin family. It is a nonamer and forms an 18-strand smooth-walled tubular ß barrel attached to the outside by the C-terminal domains. It is a mushroom-like structure which has a transmembrane pore with a central stem built of a long ß barrel. Having a uniform and stable ß barrel through the entire length of protein makes lysenin an exception among PFTs.

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Literature references

Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
Nat Commun. 2016 May 12;7:11598. doi: 10.1038/ncomms11598.
PMID: 27176125

Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein
Nat Commun. 2016 Apr 6;7:11293. doi: 10.1038/ncomms11293.
PMID: 27048994

A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis
Mol Cell Biol. 2012 Apr;32(8):1396-407. doi: 10.1128/MCB.06113-11. Epub 2012 Feb 13.
PMID: 22331463

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