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The TOM40 Family [Function: Specific diffusion channels] Seed alignment | Full alignment | TC-DB page

The translocase of the mitochondrial outer membrane (TOM complex) plays a role as the mitochondrial entry gate for most of nuclear-encoded pre-proteins. The complex mediates the translocation of pre-proteins across the mitochondrial outer membrane (MOM) via a protein-conducting pore. TOM40 comprises the root of the TOM complex and is the only known mitochondrial outer membrane protein crucial for cell viability. A homology model for TOM40 based on an X-ray structure of human VDAC1 predicted 19 ß strands. Recently, cryo-electron microscopy revealed that TOM40 forms two identical ß barrel pores in the outer membrane.

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Literature references

Cryo-EM Structure of the TOM Core Complex from Neurospora crassa
Cell. 2017 Aug 10;170(4):693-700.e7. doi: 10.1016/j.cell.2017.07.012.
PMID: 28802041

Biogenesis of beta-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence
Cell Mol Life Sci. 2009 Sep;66(17):2789-804. doi: 10.1007/s00018-009-0029-z. Epub 2009 Apr 28.
PMID: 19399587

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17742-7. doi: 10.1073/pnas.0809634105. Epub 2008 Nov 6.
PMID: 18988731

Biogenesis of mitochondrial outer membrane proteins
Biochim Biophys Acta. 2009 Jan;1793(1):42-51. doi: 10.1016/j.bbamcr.2008.04.013. Epub 2008 May 3.
PMID: 18501716

Sorting and assembly of mitochondrial outer membrane proteins
Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):557-63. doi: 10.1016/j.bbabio.2008.03.017. Epub 2008 Mar 28.
PMID: 18423394

Chaperones: inserting beta barrels into membranes
Curr Biol. 2004 Mar 9;14(5):R207-9. doi: 10.1016/j.cub.2004.02.024.
PMID: 15028240

Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins
EMBO J. 2003 May 15;22(10):2380-6. doi: 10.1093/emboj/cdg229.
PMID: 12743032

Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria
J Cell Biol. 2001 Jun 11;153(6):1151-60. doi: 10.1083/jcb.153.6.1151.
PMID: 11402060

Proteins in this family with 3D-structure
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