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The Mitochondrial and Plastid Porin MDM10 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment | TC-DB page

MDM10 is a key protein for mitochondrial morphology and inheritance. Along with Mmm1 and Mdm12, MDM10 enables the connection of mitochondria to the cytoskeleton. MDM10 is also one of TOB complex members and associated with the assembly of the TOM complex. Immunological and biochemical analysis revealed that, MDM10 is an integral outer membrane protein. Homology modelling indicated that, MDM10 is a ß barrel protein according to a b-signal which is required for the biogenesis of ß barrel proteins

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Literature references

Landscape of Eukaryotic Transmembrane Beta Barrel Proteins
J Proteome Res. 2020 Mar 6;19(3):1209-1221. doi: 10.1021/acs.jproteome.9b00740. Epub 2020 Feb 11.
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In silico analysis of coevolution among ERMES proteins, Pex11, and Lam6
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PMID: 28985476

Identification of new channels by systematic analysis of the mitochondrial outer membrane
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Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10
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Trypanosomal TAC40 constitutes a novel subclass of mitochondrial ß-barrel proteins specialized in mitochondrial genome inheritance
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PMID: 24821793

Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complex
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Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis
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PMID: 23781023

Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to ß-barrel protein assembly and maintenance of mitochondrial morphology
PLoS One. 2013 Aug 5;8(8):e71837. doi: 10.1371/journal.pone.0071837. Print 2013.
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Phylogenetic and coevolutionary analysis of the ß-barrel protein family comprised of mitochondrial porin (VDAC) and Tom40
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PMID: 22178864

Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane
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Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40
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Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa
Mol Biol Cell. 2010 May 15;21(10):1725-36. doi: 10.1091/mbc.e09-10-0844. Epub 2010 Mar 24.
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Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40
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PMID: 20111053

Mitochondrial inheritance is required for MEN-regulated cytokinesis in budding yeast
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Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10
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The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane
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A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery
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Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane
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PMID: 8089171

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