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The TGD4 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment | TC-DB page

TGD4 is conserved evolutionarily from green algae to higher plants. As indicated by the secondary structure prediction made with PROF. TGD4 appears to form multiple ß sheets especially near the C-terminus. Furthermore, it is proposed that TGD4 is a transmembrane protein, probably a ß barrel protein, present in the outer membrane of the chloroplast with its N-terminus slightly faced to the cytosol.

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Literature references

Arabidopsis TRIGALACTOSYLDIACYLGLYCEROL5 Interacts with TGD1, TGD2, and TGD4 to Facilitate Lipid Transfer from the Endoplasmic Reticulum to Plastids
Plant Cell. 2015 Oct;27(10):2941-55. doi: 10.1105/tpc.15.00394. Epub 2015 Sep 26.
PMID: 26410300

The phosphatidic acid binding site of the Arabidopsis trigalactosyldiacylglycerol 4 (TGD4) protein required for lipid import into chloroplasts
J Biol Chem. 2013 Feb 15;288(7):4763-71. doi: 10.1074/jbc.M112.438986. Epub 2013 Jan 7.
PMID: 23297418

TGD4 involved in endoplasmic reticulum-to-chloroplast lipid trafficking is a phosphatidic acid binding protein
Plant J. 2012 May;70(4):614-23. doi: 10.1111/j.1365-313X.2012.04900.x. Epub 2012 Feb 14.
PMID: 22269056

Lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis requires the extraplastidic TGD4 protein
Plant Cell. 2008 Aug;20(8):2190-204. doi: 10.1105/tpc.108.061176. Epub 2008 Aug 8.
PMID: 18689504

The PredictProtein server
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W321-6. doi: 10.1093/nar/gkh377.
PMID: 15215403

Elixir UTH dib compgen