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The TOC75 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment

The Translocon protein found at the outer-envelope-membrane of chloroplasts (TOC75) is a ß barrel integral membrane protein that belongs to the OMP85 superfamily. It acts as the protein translocation pathway on the outer membrane of chloroplast. POTRA domains of TOC75 together with TIC236 may form a continuous chaperone pathway for the translocation of pre-proteins across the intermembrane space.

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Literature references

Chloroplast Outer Membrane ß-Barrel Proteins Use Components of the General Import Apparatus
Plant Cell. 2019 Aug;31(8):1845-1855. doi: 10.1105/tpc.19.00001. Epub 2019 Jun 19.
PMID: 31217220

Structural considerations of folded protein import through the chloroplast TOC/TIC translocons
FEBS Lett. 2019 Mar;593(6):565-572. doi: 10.1002/1873-3468.13342. Epub 2019 Mar 5.
PMID: 30775779

TIC236 links the outer and inner membrane translocons of the chloroplast
Nature. 2018 Dec;564(7734):125-129. doi: 10.1038/s41586-018-0713-y. Epub 2018 Nov 21.
PMID: 30464337

The outer membrane Omp85-like protein P39 influences metabolic homeostasis in mature Arabidopsis thaliana
Plant Biol (Stuttg). 2018 Sep;20(5):825-833. doi: 10.1111/plb.12839. Epub 2018 Jun 4.
PMID: 29758131

Structural components involved in plastid protein import
Essays Biochem. 2018 Apr 13;62(1):65-75. doi: 10.1042/EBC20170093. Print 2018 Apr 13.
PMID: 29487196

Stable megadalton TOC-TIC supercomplexes as major mediators of protein import into chloroplasts
Plant J. 2017 Oct;92(2):178-188. doi: 10.1111/tpj.13643. Epub 2017 Sep 15.
PMID: 28745032

Chloroplast outer envelope protein P39 in Arabidopsis thaliana belongs to the Omp85 protein family
Proteins. 2017 Aug;85(8):1391-1401. doi: 10.1002/prot.24725. Epub 2017 Jun 12.
PMID: 25401771

The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts
Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4868-E4876. doi: 10.1073/pnas.1621179114. Epub 2017 May 30.
PMID: 28559331

Polypeptide Transport-Associated Domains of the Toc75 Channel Protein Are Located in the Intermembrane Space of Chloroplasts
Plant Physiol. 2016 Sep;172(1):235-43. doi: 10.1104/pp.16.00919. Epub 2016 Jul 7.
PMID: 27388682

Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import
Elife. 2016 Mar 21;5:e12631. doi: 10.7554/eLife.12631.
PMID: 26999824

Toxoplasma gondii Toc75 Functions in Import of Stromal but not Peripheral Apicoplast Proteins
Traffic. 2015 Dec;16(12):1254-69. doi: 10.1111/tra.12333. Epub 2015 Nov 2.
PMID: 26381927

The Omp85-type outer membrane protein p36 of Arabidopsis thaliana evolved by recent gene duplication
J Plant Res. 2015 Mar;128(2):317-25. doi: 10.1007/s10265-014-0693-4. Epub 2015 Jan 22.
PMID: 25608613

New insights into the mechanism of chloroplast protein import and its integration with protein quality control, organelle biogenesis and development
J Mol Biol. 2015 Mar 13;427(5):1038-1060. doi: 10.1016/j.jmb.2014.08.016. Epub 2014 Aug 28.
PMID: 25174336

Targeting and assembly of components of the TOC protein import complex at the chloroplast outer envelope membrane
Front Plant Sci. 2014 Jun 11;5:269. doi: 10.3389/fpls.2014.00269. eCollection 2014.
PMID: 24966864

Toc33 and Toc64-III cooperate in precursor protein import into the chloroplasts of Arabidopsis thaliana
Plant Cell Environ. 2013 May;36(5):970-83. doi: 10.1111/pce.12030. Epub 2013 Jan 7.
PMID: 23131143

Neofunctionalization within the Omp85 protein superfamily during chloroplast evolution
Plant Signal Behav. 2012 Feb;7(2):161-4. doi: 10.4161/psb.18677. Epub 2012 Feb 1.
PMID: 22307047

Two evolutionarily conserved essential beta-barrel proteins in the chloroplast outer envelope membrane
Biosci Trends. 2009 Oct;3(5):168-78.
PMID: 20103843

A molecular-genetic study of the Arabidopsis Toc75 gene family
Plant Physiol. 2005 Jun;138(2):715-33. doi: 10.1104/pp.105.063289. Epub 2005 May 20.
PMID: 15908591

Topology studies of the chloroplast protein import channel Toc75
Biol Chem. 2000 Aug;381(8):687-93. doi: 10.1515/BC.2000.089.
PMID: 11030426

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