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The Chloroplast Outer Envelope Protein 80 (OEP80) Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment | TC-DB page

OEP80 is another OMP85 homolog, whose function is obscure. It is also referred to as TOC75-V since it is encoded in the V chromosome of Arabidopsis thaliana. Multiple structural studies in OMP85 homologs have detected a conserved folding pattern of POTRA domains and the unparalleled arrangement of the transmembrane ß barrel. Phylogenetic analysis supported the grouping of TOC75 and OEP80 sister to OMP85. OEP80 has a vital role in the insertion of ß barrel proteins into the chloroplastic outer membrane.OEP80 has a cleavable N-terminal signal and, in addition, its POTRA domains are exposed to the intermembrane space of chloroplast. Thus, OEP80 seems to interact with chloroplast substrates.

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Literature references

Chloroplast Outer Membrane ß-Barrel Proteins Use Components of the General Import Apparatus
Plant Cell. 2019 Aug;31(8):1845-1855. doi: 10.1105/tpc.19.00001. Epub 2019 Jun 19.
PMID: 31217220

The outer membrane Omp85-like protein P39 influences metabolic homeostasis in mature Arabidopsis thaliana
Plant Biol (Stuttg). 2018 Sep;20(5):825-833. doi: 10.1111/plb.12839. Epub 2018 Jun 4.
PMID: 29758131

The Omp85-type outer membrane protein p36 of Arabidopsis thaliana evolved by recent gene duplication
J Plant Res. 2015 Mar;128(2):317-25. doi: 10.1007/s10265-014-0693-4. Epub 2015 Jan 22.
PMID: 25608613

Evolution and targeting of Omp85 homologs in the chloroplast outer envelope membrane
Front Plant Sci. 2014 Oct 13;5:535. doi: 10.3389/fpls.2014.00535. eCollection 2014.
PMID: 25352854

Structure and function of POTRA domains of Omp85/TPS superfamily
Int Rev Cell Mol Biol. 2014;308:1-34. doi: 10.1016/B978-0-12-800097-7.00001-4.
PMID: 24411168

The structural basis of autotransporter translocation by TamA
Nat Struct Mol Biol. 2013 Nov;20(11):1318-20. doi: 10.1038/nsmb.2689. Epub 2013 Sep 22.
PMID: 24056943

Structural insight into the biogenesis of ß-barrel membrane proteins
Nature. 2013 Sep 19;501(7467):385-90. doi: 10.1038/nature12521. Epub 2013 Sep 1.
PMID: 23995689

Neofunctionalization within the Omp85 protein superfamily during chloroplast evolution
Plant Signal Behav. 2012 Feb;7(2):161-4. doi: 10.4161/psb.18677. Epub 2012 Feb 1.
PMID: 22307047

OEP80, an essential protein paralogous to the chloroplast protein translocation channel Toc75, exists as a 70-kD protein in the Arabidopsis thaliana chloroplast outer envelope
Plant Mol Biol. 2012 Jan;78(1-2):147-58. doi: 10.1007/s11103-011-9853-2. Epub 2011 Nov 18.
PMID: 22094888

Emerging roles of the chloroplast outer envelope membrane
Trends Plant Sci. 2011 Oct;16(10):550-7. doi: 10.1016/j.tplants.2011.06.005. Epub 2011 Jul 19.
PMID: 21775189

In vivo analyses of the roles of essential Omp85-related proteins in the chloroplast outer envelope membrane
Plant Physiol. 2011 Sep;157(1):147-59. doi: 10.1104/pp.111.181891. Epub 2011 Jul 14.
PMID: 21757633

Two evolutionarily conserved essential beta-barrel proteins in the chloroplast outer envelope membrane
Biosci Trends. 2009 Oct;3(5):168-78.
PMID: 20103843

Two distinct Omp85 paralogs in the chloroplast outer envelope membrane are essential for embryogenesis in Arabidopsis thaliana
Plant Signal Behav. 2008 Dec;3(12):1134-5. doi: 10.4161/psb.3.12.7095.
PMID: 19704458

The Omp85-related chloroplast outer envelope protein OEP80 is essential for viability in Arabidopsis
Plant Physiol. 2008 Sep;148(1):235-45. doi: 10.1104/pp.108.122754. Epub 2008 Jul 11.
PMID: 18621981

Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily
Science. 2007 Aug 17;317(5840):957-61. doi: 10.1126/science.1143860.
PMID: 17702945

The chloroplastic protein translocation channel Toc75 and its paralog OEP80 represent two distinct protein families and are targeted to the chloroplastic outer envelope by different mechanisms
Plant J. 2004 Aug;39(3):354-65. doi: 10.1111/j.1365-313X.2004.02135.x.
PMID: 15255865

A Toc75-like protein import channel is abundant in chloroplasts
EMBO Rep. 2002 Jun;3(6):557-62. doi: 10.1093/embo-reports/kvf110. Epub 2002 May 24.
PMID: 12034753

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