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The VP1243 Family [Function: Active transporters] Seed alignment | Full alignment

Vibrio parahaemolyticus is a significant Gram-negative halophilous pathogen. As a result of the consumption of seafood, it may cause a harmful seafood-borne illness in humans. In addition, it causes a wide range of disease in aquatic animals. Avoiding the use of antibiotics, VP1243 is a protective antigen which showed a high effective antimicrobial activity against the mentioned organism. VP1243 is widely distributed and highly conserved among the major Vibrio species. VP1243 is considered as a hopeful candidate against the Vibrio infections. Western blotting analysis revealed that VP1243 is an outer membrane protein. The first 19 amino acids function as a signal peptide according to SignalP. VP1243 forms 10 transmembrane ß strands based on PRED-TMBB2 prediction.

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Literature references

Evaluation of the ß-barrel outer membrane protein VP1243 as a candidate antigen for a cross-protective vaccine against Vibrio infections
Microb Pathog. 2020 Oct;147:104419. doi: 10.1016/j.micpath.2020.104419. Epub 2020 Aug 5.
PMID: 32768517

Landscape of Eukaryotic Transmembrane Beta Barrel Proteins
J Proteome Res. 2020 Mar 6;19(3):1209-1221. doi: 10.1021/acs.jproteome.9b00740. Epub 2020 Feb 11.
PMID: 32008325

Helix-strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3
J Gen Physiol. 2019 Apr 1;151(4):489-504. doi: 10.1085/jgp.201812272. Epub 2019 Jan 23.
PMID: 30674561

Identification of a novel vaccine candidate by immunogenic screening of Vibrio parahaemolyticus outer membrane proteins
Vaccine. 2014 Oct 21;32(46):6115-21. doi: 10.1016/j.vaccine.2014.08.077. Epub 2014 Sep 16.
PMID: 25236587

Influence of protein-micelle ratios and cysteine residues on the kinetic stability and unfolding rates of human mitochondrial VDAC-2
PLoS One. 2014 Jan 29;9(1):e87701. doi: 10.1371/journal.pone.0087701. eCollection 2014.
PMID: 24494036

The structural biology of ß-barrel membrane proteins: a summary of recent reports
Curr Opin Struct Biol. 2011 Aug;21(4):523-31. doi: 10.1016/ Epub 2011 Jun 28.
PMID: 21719274

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