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The Helicobacter outer membrane protein (HP_OMP) Family [Function: Adhesion] Seed alignment | Full alignment | Pfam page | TC-DB page

This family consists of several outer membrane proteins found only in Helicobacter pylori, which is the causative agent of gastritis and peptic ulceration in humans. The outer membrane proteome profile of Helicobacter pylori differs from that of other Gram-negative bacteria. Outer membrane proteins of Helicobacter pylori are characterized mainly as adhesins and porins and extensive C-terminal sequence similarity between these proteins has been used to define this large paralogous family.The outer membrane proteins of Helicobacter pylori are anchored to the cell surface via “Hp_OMP” domain found at the C?terminus, which requires their assembly by the ß?barrel assembly machinery (BAM).

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Literature references

Reductive evolution in outer membrane protein biogenesis has not compromised cell surface complexity in Helicobacter pylori
Microbiologyopen. 2017 Dec;6(6):e00513. doi: 10.1002/mbo3.513. Epub 2017 Oct 21.
PMID: 29055967

Helicobacter pylori Outer Membrane Protein-Related Pathogenesis
Toxins (Basel). 2017 Mar 11;9(3):101. doi: 10.3390/toxins9030101.
PMID: 28287480

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA
Nat Microbiol. 2016 Oct 17;2:16188. doi: 10.1038/nmicrobiol.2016.188.
PMID: 27748756

Topology and membrane interaction of Helicobacter pylori ComB proteins involved in natural transformation competence
Int J Med Microbiol. 2003 Jun;293(2-3):153-65. doi: 10.1078/1438-4221-00258.
PMID: 12868652

Characterization of four members of a multigene family encoding outer membrane proteins of Helicobacter pylori and their potential for vaccination
Microbes Infect. 2001 Mar;3(3):171-9. doi: 10.1016/s1286-4579(01)01377-6.
PMID: 11358711

Functional expression in Escherichia coli and membrane topology of porin HopE, a member of a large family of conserved proteins in Helicobacter pylori
J Bacteriol. 2000 May;182(9):2370-5. doi: 10.1128/jb.182.9.2370-2375.2000.
PMID: 10762234

Isolation and characterization of a conserved porin protein from Helicobacter pylori
J Bacteriol. 1995 Oct;177(19):5447-52. doi: 10.1128/jb.177.19.5447-5452.1995.
PMID: 7559328

Isolation and characterization of a family of porin proteins from Helicobacter pylori
Infect Immun. 1995 Apr;63(4):1567-72. doi: 10.1128/IAI.63.4.1567-1572.1995.
PMID: 7534278

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