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The Nucleoside-specific channel-forming protein (Tsx) Family [Function: Specific diffusion channels] Seed alignment | Full alignment | Pfam page | Pfam Wiki page | TC-DB page

Proteins of the Tsx family are nucleoside-specific receptors. Their roles vary from ribonucleosides and deoxyribonucleosides transport to receptors for bacteriophages and colicins. The crystal structure of Tsx of Escherchia coli revealed a monomeric 12-stranded ß-barrel with a long narrow channel spanning the outer membrane. The structure provides a mechanism for nucleoside transport across the bacterial outer membrane. The channel which is shaped like a keyhole has two distinct and well defined nucleoside-binding sites. Nucleoside transport presumably occurs by diffusion from one binding site to the next.

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Literature references

Crystal structure of the bacterial nucleoside transporter Tsx
EMBO J. 2004 Aug 18;23(16):3187-95. doi: 10.1038/sj.emboj.7600330. Epub 2004 Jul 22.
PMID: 15272310

The nucleoside-specific Tsx channel from the outer membrane of Salmonella typhimurium, Klebsiella pneumoniae and Enterobacter aerogenes: functional characterization and DNA sequence analysis of the tsx genes
Microbiology (Reading). 1997 Feb;143 ( Pt 2):603-15. doi: 10.1099/00221287-143-2-603.
PMID: 9043137

Proteins in this family with 3D-structure
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