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The Type specific antigen (TSA) Family [Function: Adhesion ] Seed alignment | Full alignment | Pfam page

This family consists of several antigenic variants in the genera Rickettsia and Orientia belonging to the family Rickettsiaceae. Rickettsioses are arthropod-borne zoonoses caused by intracellular bacteria of the Rickettsiaceae. A type-specific antigen (TSA) of 56-kilodaltons located on the rickettsial surface is responsible for the variation. Orientia tsutsugamushi (O. tsutsugamushi), the causative agent of scrub typhus, is an obligate intracellular pathogen. O. tsutsugamushi has three major outer membrane proteins: TSA56, TSA47 and TSA22. The TSA56 is the major outer membrane protein required for O. tsutsugamushi adhesion.

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Literature references

Longevity of antibody and T-cell responses against outer membrane antigens of Orientia tsutsugamushi in scrub typhus patients
Emerg Microbes Infect. 2017 Dec 20;6(12):e116. doi: 10.1038/emi.2017.106.
PMID: 29259327

Protective immunity of 56-kDa type-specific antigen of Orientia tsutsugamushi causing scrub typhus
J Microbiol Biotechnol. 2014 Dec 28;24(12):1728-35. doi: 10.4014/jmb.1407.07048.
PMID: 25112312

Molecular characterization of three major outer membrane proteins, TSA56, TSA47 and TSA22, in Orientia tsutsugamushi
Int J Mol Med. 2012 Jul;30(1):75-84. doi: 10.3892/ijmm.2012.967. Epub 2012 Apr 10.
PMID: 22505220

Diversity of immunodominant 56-kDa type-specific antigen (TSA) of Rickettsia tsutsugamushi. Sequence and comparative analyses of the genes encoding TSA homologues from four antigenic variants
J Biol Chem. 1992 Jun 25;267(18):12728-35.
PMID: 1618776

Purification and partial characterization of a type-specific antigen of Rickettsia tsutsugamushi
Infect Immun. 1989 May;57(5):1427-31. doi: 10.1128/IAI.57.5.1427-1431.1989.
PMID: 2496028

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