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The Outer membrane protein beta-barrel domain (OMP_b-brl) Family [Function: Adhesion ] Seed alignment | Full alignment | Pfam page | TC-DB page

This domain is found in a wide range of outer membrane proteins, found mainly in Alphaproteobacteria.Examples are the Major Outer Membrane Protein (ompP1) from various strains of Coxiella burnetti, which possesses the typical porin properties: it is heat-modifiable, it has channel activity and is predicted to form a ß-barrel; Omp3b from Brucella abortus and homologs from various Alphaproteobacteria that are believed to be involved in bacterial surface control and host cell interactions. In Pseudomonas aeruginosa, OprH forms an 8-stranded ß-barrel protein with four extracellular loops of unequal size. Using in vivo and in vitro biochemical assays, OprH indeed interacts with LPS in P. aeruginosa outer membranes. In Yersinia pestis the causative agent of plague, the outer membrane protein Ail (Adhesion invasion locus) is one of the most highly expressed proteins on the cell surface.

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Literature references

Optimizing nanodiscs and bicelles for solution NMR studies of two ß-barrel membrane proteins
J Biomol NMR. 2015 Apr;61(3-4):261-74. doi: 10.1007/s10858-015-9905-z. Epub 2015 Feb 10.
PMID: 25869397

Structural basis for the interaction of lipopolysaccharide with outer membrane protein H (OprH) from Pseudomonas aeruginosa
J Biol Chem. 2011 Nov 11;286(45):39211-23. doi: 10.1074/jbc.M111.280933. Epub 2011 Aug 24.
PMID: 21865172

Temporal analysis of Coxiella burnetii morphological differentiation
J Bacteriol. 2004 Nov;186(21):7344-52. doi: 10.1128/JB.186.21.7344-7352.2004.
PMID: 15489446

Cloning and porin activity of the major outer membrane protein P1 from Coxiella burnetii
Infect Immun. 2002 Dec;70(12):6741-50. doi: 10.1128/iai.70.12.6741-6750.2002.
PMID: 12438349

Membrane topology of the outer membrane protein OprH from Pseudomonas aeruginosa: PCR-mediated site-directed insertion and deletion mutagenesis
J Bacteriol. 1996 Jun;178(11):3346-9. doi: 10.1128/jb.178.11.3346-3349.1996.
PMID: 8655519

Pseudomonas aeruginosa outer membrane protein OprH: expression from the cloned gene and function in EDTA and gentamicin resistance
J Bacteriol. 1991 Nov;173(21):6657-64. doi: 10.1128/jb.173.21.6657-6664.1991.
PMID: 1938872

Proteins in this family with 3D-structure
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