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The Chlamydia major outer membrane protein Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | Pfam page | TC-DB page

The Chlamydial Major Outer Membrane Protein (MOMP), functions to permit the diffusion of solutes through the intrareticular body membrane. MOMP is predicted to form a ß barrel, with 4 highly variable and immunogenic extracellular loops that determine the different serotypes. The four variable loops are not required for pore formation but rather serve in the modification of the channel function. 7 cysteines are found conserved in these loops, and disulfide bonds are formed between Cys(48)-Cys(55), Cys(201)-Cys(203), whereas Cys(51), Cys(136), Cys(226), and Cys(351), are free cysteines and, therefore, could potentially form disulfide-linked complexes with other MOMPs or other membrane components.

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Literature references

Super-Resolution Fluorescence Microscopy Reveals Clustering Behaviour of Chlamydia pneumoniae's Major Outer Membrane Protein
Biology (Basel). 2020 Oct 20;9(10):344. doi: 10.3390/biology9100344.
PMID: 33092039

Vaccination with the recombinant major outer membrane protein elicits long-term protection in mice against vaginal shedding and infertility following a Chlamydia muridarum genital challenge
NPJ Vaccines. 2020 Oct 1;5:90. doi: 10.1038/s41541-020-00239-7. eCollection 2020.
PMID: 33083025

Capturing Complex Vaccine-Immune-Disease Relationships for Free-Ranging Koalas: Higher Chlamydial Loads Are Associated With Less IL17 Expression and More Chlamydial Disease
Front Vet Sci. 2020 Sep 25;7:530686. doi: 10.3389/fvets.2020.530686. eCollection 2020.
PMID: 33102563

A nanovaccine formulation of Chlamydia recombinant MOMP encapsulated in PLGA 85:15 nanoparticles augments CD4(+) effector (CD44(high) CD62L(low)) and memory (CD44(high) CD62L(high)) T-cells in immunized mice
Nanomedicine. 2020 Oct;29:102257. doi: 10.1016/j.nano.2020.102257. Epub 2020 Jun 28.
PMID: 32610072

Protection against a chlamydial respiratory challenge by a chimeric vaccine formulated with the Chlamydia muridarum major outer membrane protein variable domains using the Neisseria lactamica porin B as a scaffold
NPJ Vaccines. 2020 May 8;5:37. doi: 10.1038/s41541-020-0182-9. eCollection 2020.
PMID: 32411400

A Recombinant Chlamydia trachomatis MOMP Vaccine Elicits Cross-serogroup Protection in Mice Against Vaginal Shedding and Infertility
J Infect Dis. 2020 Jan 2;221(2):191-200. doi: 10.1093/infdis/jiz438.
PMID: 31504647

MOMP and MIP DNA-loaded bacterial ghosts reduce the severity of lung lesions in mice after Chlamydia psittaci respiratory tract infection
Immunobiology. 2019 Nov;224(6):739-746. doi: 10.1016/j.imbio.2019.09.002. Epub 2019 Sep 6.
PMID: 31561842

Obtaining an ELISA test based on a recombinant protein of Chlamydia trachomatis
Int Microbiol. 2019 Dec;22(4):471-478. doi: 10.1007/s10123-019-00074-4. Epub 2019 Apr 11.
PMID: 30976995

Therapeutic effect of a Chlamydia pecorum recombinant major outer membrane protein vaccine on ocular disease in koalas (Phascolarctos cinereus)
PLoS One. 2019 Jan 7;14(1):e0210245. doi: 10.1371/journal.pone.0210245. eCollection 2019.
PMID: 30615687

A recombinant multi-epitope peptide vaccine based on MOMP and CPSIT_p6 protein protects against Chlamydia psittaci lung infection
Appl Microbiol Biotechnol. 2019 Jan;103(2):941-952. doi: 10.1007/s00253-018-9513-4. Epub 2018 Nov 23.
PMID: 30467705

CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients
Immunobiology. 2019 Jan;224(1):34-41. doi: 10.1016/j.imbio.2018.10.010. Epub 2018 Nov 20.
PMID: 30477893

Spectroscopic analysis of chlamydial major outer membrane protein in support of structure elucidation
Protein Sci. 2018 Nov;27(11):1923-1941. doi: 10.1002/pro.3501.
PMID: 30144190

Predicting tubal factor infertility by using markers of humoral and cell-mediated immune response against Chlamydia trachomatis
Am J Reprod Immunol. 2018 Nov;80(5):e13051. doi: 10.1111/aji.13051. Epub 2018 Oct 3.
PMID: 30281189

Vaccination of koalas (Phascolarctos cinereus) against Chlamydia pecorum using synthetic peptides derived from the major outer membrane protein
PLoS One. 2018 Jun 28;13(6):e0200112. doi: 10.1371/journal.pone.0200112. eCollection 2018.
PMID: 29953523

The bioinformatics analyses reveal novel antigen epitopes in major outer membrane protein of Chlamydia trachomatis
Indian J Med Microbiol. 2017 Oct-Dec;35(4):522-528. doi: 10.4103/ijmm.IJMM_17_251.
PMID: 29405144

Cell-free production of a functional oligomeric form of a Chlamydia major outer-membrane protein (MOMP) for vaccine development
J Biol Chem. 2017 Sep 8;292(36):15121-15132. doi: 10.1074/jbc.M117.784561. Epub 2017 Jul 24.
PMID: 28739800

Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS
PLoS One. 2017 May 11;12(5):e0177653. doi: 10.1371/journal.pone.0177653. eCollection 2017.
PMID: 28494018

Evaluation of tandem Chlamydia trachomatis MOMP multi-epitopes vaccine in BALB/c mice model
Vaccine. 2017 May 25;35(23):3096-3103. doi: 10.1016/j.vaccine.2017.04.031. Epub 2017 Apr 26.
PMID: 28456528

Comparison of the nine polymorphic membrane proteins of Chlamydia trachomatis for their ability to induce protective immune responses in mice against a C. muridarum challenge
Vaccine. 2017 May 2;35(19):2543-2549. doi: 10.1016/j.vaccine.2017.03.070. Epub 2017 Apr 3.
PMID: 28385608

The cationic liposomal adjuvants CAF01 and CAF09 formulated with the major outer membrane protein elicit robust protection in mice against a Chlamydia muridarum respiratory challenge
Vaccine. 2017 Mar 23;35(13):1705-1711. doi: 10.1016/j.vaccine.2017.02.020. Epub 2017 Feb 24.
PMID: 28238632

Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen
APMIS. 2016 Dec;124(12):1078-1086. doi: 10.1111/apm.12605.
PMID: 27859689

Recombinant expression of Chlamydia trachomatis major outer membrane protein in E. Coli outer membrane as a substrate for vaccine research
BMC Microbiol. 2016 Jul 27;16(1):165. doi: 10.1186/s12866-016-0787-3.
PMID: 27464881

Characterization of the disulfide bonds and free cysteine residues of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein
Biochemistry. 2005 Apr 26;44(16):6250-6. doi: 10.1021/bi047775v.
PMID: 15835913

Surface expression, single-channel analysis and membrane topology of recombinant Chlamydia trachomatis Major Outer Membrane Protein
BMC Microbiol. 2005 Jan 26;5:5. doi: 10.1186/1471-2180-5-5.
PMID: 15673471

Prediction of the membrane-spanning beta-strands of the major outer membrane protein of Chlamydia
Protein Sci. 2002 Jul;11(7):1854-61. doi: 10.1110/ps.3650102.
PMID: 12070338

Mutagenesis and functional reconstitution of chlamydial major outer membrane proteins: VS4 domains are not required for pore formation but modify channel function
Infect Immun. 2001 Mar;69(3):1671-8. doi: 10.1128/IAI.69.3.1671-1678.2001.
PMID: 11179342

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