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The Leptospira porin OmpL1 Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | Pfam page | TC-DB page

This family consists of proteins found in spirochetes of the genus Leptospira. OmpL1, is a heat modifiable porin that can form trimeric structures. OmpL1 has been reconstituted in planar lipid bilayers where an average single channel conductance similar to those of the major porin activity of native leptospiral membranes, was demonstrated. OmpL1 is expressed during infection and, therefore, has a role in the induction and persistence of leptospiral interstitial nephritis.

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Literature references

Chimeric epitope vaccine against Leptospira interrogans infection and induced specific immunity in guinea pigs
BMC Microbiol. 2016 Oct 14;16(1):241. doi: 10.1186/s12866-016-0852-y.
PMID: 27737644

The Miller Hypothesis
For Immunopathol Dis Therap. 2016;7(3-4):167-174. doi: 10.1615/ForumImmunDisTher.2017020293.
PMID: 30701122

Comparison of Immunoprotection of Leptospira Recombinant Proteins with conventional vaccine in experimental animals
Indian J Exp Biol. 2015 Dec;53(12):779-85.
PMID: 26742322

Molecular identification of the ompL1 gene within Leptospira interrogans standard serovars
J Infect Dev Ctries. 2014 Jun 11;8(6):688-93. doi: 10.3855/jidc.3174.
PMID: 24916865

Recombinant OmpL1 protein as a diagnostic antigen for the detection of canine leptospirosis
Appl Biochem Biotechnol. 2013 Jan;169(2):431-7. doi: 10.1007/s12010-012-9973-4. Epub 2012 Dec 5.
PMID: 23212848

OmpL1 is an extracellular matrix- and plasminogen-interacting protein of Leptospira spp
Infect Immun. 2012 Oct;80(10):3679-92. doi: 10.1128/IAI.00474-12. Epub 2012 Jul 16.
PMID: 22802342

A sensitive and specific IgM-ELISA for the serological diagnosis of human leptospirosis using a rLipL32/1-LipL21-OmpL1/2 fusion protein
Biomed Environ Sci. 2011 Jun;24(3):291-9. doi: 10.3967/0895-3988.2011.03.013.
PMID: 21784316

Characterization of conserved combined T and B cell epitopes in Leptospira interrogans major outer membrane proteins OmpL1 and LipL41
BMC Microbiol. 2011 Jan 26;11(1):21. doi: 10.1186/1471-2180-11-21.
PMID: 21269437

Leptospira: a spirochaete with a hybrid outer membrane
Mol Microbiol. 2010 Aug;77(4):805-14. doi: 10.1111/j.1365-2958.2010.07262.x. Epub 2010 Jun 28.
PMID: 20598085

Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection
Infect Immun. 1999 Dec;67(12):6572-82.
PMID: 10569777

Expression and distribution of leptospiral outer membrane components during renal infection of hamsters
Infect Immun. 1999 Feb;67(2):853-61. doi: 10.1128/IAI.67.2.853-861.1999.
PMID: 9916100

The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin
Infect Immun. 1995 Aug;63(8):3174-81. doi: 10.1128/IAI.63.8.3174-3181.1995.
PMID: 7622245

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