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The DUF3373 (Campylobacter omp50) Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | Pfam page | TC-DB page

Proteins of this family are found in Campylobacter jejuni and Campylobacter lari but not in Campylobacter coli, although the respective gene was detected in some cases in all three species by PCR. The protein shows a pore-forming activity, with cation selective channel properties. No significant similarity exists between omp50 and the members of the MOMP family of Campylobacter which is in agreement with the absence of antigenic cross-reactivity between these two proteins.

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Literature references

Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling
Cell Host Microbe. 2012 Jul 19;12(1):47-59. doi: 10.1016/j.chom.2012.05.018.
PMID: 22817987

Use of the omp50 gene for identification of Campylobacter species by PCR
J Clin Microbiol. 2004 May;42(5):2301-5. doi: 10.1128/jcm.42.5.2301-2305.2004.
PMID: 15131219

Purification, characterization and sequence analysis of Omp50,a new porin isolated from Campylobacter jejuni
Biochem J. 2000 Dec 15;352 Pt 3(Pt 3):637-43.
PMID: 11104668

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