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The DUF3573 (FslE) Family [Function: Active transporters] Seed alignment | Full alignment | Pfam page | TC-DB page

Strains of Francisella tularensis secrete a siderophore in response to iron limitation. FslE belongs to a family of proteins that has no known homologs outside of the Francisella species and the fslE gene product has been shown to be localized on the outer membrane of F. tularensis. Experimental data suggest that FslE may function as the siderophore receptor in F. tularensis. Using a plate-based growth assay, it was found that the mutant was able to secrete a siderophore but was defective in the utilization of the siderophore. Prediction methods suggest that the ß-barrel domain is localized to the C-terminus of the protein similar to the family of TonB-dependent receptors.

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Literature references

Two parallel pathways for ferric and ferrous iron acquisition support growth and virulence of the intracellular pathogen Francisella tularensis Schu S4
Microbiologyopen. 2016 Jun;5(3):453-68. doi: 10.1002/mbo3.342. Epub 2016 Feb 25.
PMID: 26918301

The FupA/B protein uniquely facilitates transport of ferrous iron and siderophore-associated ferric iron across the outer membrane of Francisella tularensis live vaccine strain
Microbiology (Reading). 2014 Feb;160(Pt 2):446-457. doi: 10.1099/mic.0.072835-0. Epub 2013 Dec 4.
PMID: 24307666

Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensis
J Biol Chem. 2012 Jul 20;287(30):25191-202. doi: 10.1074/jbc.M112.371856. Epub 2012 Jun 1.
PMID: 22661710

fslE is necessary for siderophore-mediated iron acquisition in Francisella tularensis Schu S4
J Bacteriol. 2008 Aug;190(15):5353-61. doi: 10.1128/JB.00181-08. Epub 2008 Jun 6.
PMID: 18539739

Characterization of Francisella tularensis outer membrane proteins
J Bacteriol. 2007 Jan;189(2):561-74. doi: 10.1128/JB.01505-06. Epub 2006 Nov 17.
PMID: 17114266

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