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The N4 bacteriophage Receptor (nfrA) Family [Function: Adhesion] Seed alignment | Full alignment | Pfam page | TC-DB page

NfrA of Escherichia coli was found to be one of the two genes whose products are required for bacteriophage N4 adsorption. The nfrA gene encodes a 990-residue long outer membrane protein which presumably serves as the phage receptor, whereas the nfrB gene encodes an inner membrane protein and may be a component of the receptor. Besides acting as receptor for N4 bacteriophage, the physiological role of nrfA is unknown. The transmembrane domain of the protein is located in the C-terminus whereas a large N-terminal periplasmic domain of unknown function (TPR) domain, which is known to be associated with protein-protein interactions, is also present.

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Literature references

Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
Nat Commun. 2019 Jul 25;10(1):3325. doi: 10.1038/s41467-019-11129-5.
PMID: 31346171

Biogenesis and function of the autotransporter adhesins YadA, intimin and invasin
Int J Med Microbiol. 2019 Jul;309(5):331-337. doi: 10.1016/j.ijmm.2019.05.009. Epub 2019 Jun 1.
PMID: 31176600

Characterization of Tail Sheath Protein of N4-Like Phage phiAxp-3
Front Microbiol. 2018 Mar 15;9:450. doi: 10.3389/fmicb.2018.00450. eCollection 2018.
PMID: 29599760

Secretion of the Intimin Passenger Domain Is Driven by Protein Folding
J Biol Chem. 2016 Sep 16;291(38):20096-112. doi: 10.1074/jbc.M116.731497. Epub 2016 Jul 27.
PMID: 27466361

Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family
Genome Biol Evol. 2016 Jun 13;8(6):1690-705. doi: 10.1093/gbe/evw112.
PMID: 27190006

The inverse autotransporter family: intimin, invasin and related proteins
Int J Med Microbiol. 2015 Feb;305(2):276-82. doi: 10.1016/j.ijmm.2014.12.011. Epub 2014 Dec 24.
PMID: 25596886

The inverse autotransporter intimin exports its passenger domain via a hairpin intermediate
J Biol Chem. 2015 Jan 16;290(3):1837-49. doi: 10.1074/jbc.M114.604769. Epub 2014 Dec 8.
PMID: 25488660

The Intimin periplasmic domain mediates dimerisation and binding to peptidoglycan
Mol Microbiol. 2015 Jan;95(1):80-100. doi: 10.1111/mmi.12840. Epub 2014 Nov 24.
PMID: 25353290

Intimin and invasin export their C-terminus to the bacterial cell surface using an inverse mechanism compared to classical autotransport
PLoS One. 2012;7(10):e47069. doi: 10.1371/journal.pone.0047069. Epub 2012 Oct 9.
PMID: 23056583

The tail sheath of bacteriophage N4 interacts with the Escherichia coli receptor
J Bacteriol. 2009 Jan;191(2):525-32. doi: 10.1128/JB.01423-08. Epub 2008 Nov 14.
PMID: 19011026

Proteomic analysis of the Escherichia coli outer membrane
Eur J Biochem. 2000 May;267(10):2871-81. doi: 10.1046/j.1432-1327.2000.01296.x.
PMID: 10806384

Two overlapping genes encoding membrane proteins required for bacteriophage N4 adsorption
J Bacteriol. 1993 Nov;175(21):7081-5. doi: 10.1128/jb.175.21.7081-7085.1993.
PMID: 8226649

Genetic analysis of bacteriophage N4 adsorption
J Bacteriol. 1989 Sep;171(9):4595-602. doi: 10.1128/jb.171.9.4595-4602.1989.
PMID: 2670887

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