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The capsule assembly protein Wzi Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment | Pfam page | TC-DB page

This family consists of homologs to the wzi protein of E.coli. Wzi was found to be involved in the surface assembly of the Escherichia coli K30 group 1 capsule, participating in the translocation of group 1 capsular polysaccharide in co-operation with the wza complex. Wzi is an outer membrane monomeric 18-stranded ß-barrel protein. Homologs are also found in genera Klebsiella pneumoniae, Acinetobacter, Psychrobacter, Shewanella oneidensis, Rhodobacter sphaeroides, Idiomarina loihiensis and Microbulbifer degradans.

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Literature references

EasyPrimer: user-friendly tool for pan-PCR/HRM primers design. Development of an HRM protocol on wzi gene for fast Klebsiella pneumoniae typing
Sci Rep. 2020 Jan 28;10(1):1307. doi: 10.1038/s41598-020-57742-z.
PMID: 31992749

Molecular Characterization of Carbapenem Resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae Isolated from Lebanon
Sci Rep. 2019 Jan 24;9(1):531. doi: 10.1038/s41598-018-36554-2.
PMID: 30679463

Key diffusion mechanisms involved in regulating bidirectional water permeation across E. coli outer membrane lectin
Sci Rep. 2016 Jun 20;6:28157. doi: 10.1038/srep28157.
PMID: 27320406

Genotypes of Ciprofloxacin-Resistant Klebsiella pneumoniae in Korea and Their Characteristics According to the Genetic Lineages
Microb Drug Resist. 2015 Dec;21(6):622-30. doi: 10.1089/mdr.2015.0001. Epub 2015 Jul 24.
PMID: 26207318

wzi Gene sequencing, a rapid method for determination of capsular type for Klebsiella strains
J Clin Microbiol. 2013 Dec;51(12):4073-8. doi: 10.1128/JCM.01924-13. Epub 2013 Oct 2.
PMID: 24088853

Encapsulating bacteria
Structure. 2013 May 7;21(5):692-3. doi: 10.1016/j.str.2013.04.011.
PMID: 23664360

Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli
Structure. 2013 May 7;21(5):844-53. doi: 10.1016/j.str.2013.03.010. Epub 2013 Apr 25.
PMID: 23623732

Three-dimensional structure of Wza, the protein required for translocation of group 1 capsular polysaccharide across the outer membrane of Escherichia coli
J Biol Chem. 2004 Jul 2;279(27):28227-32. doi: 10.1074/jbc.M402913200. Epub 2004 Apr 16.
PMID: 15090537

A novel outer membrane protein, Wzi, is involved in surface assembly of the Escherichia coli K30 group 1 capsule
J Bacteriol. 2003 Oct;185(19):5882-90. doi: 10.1128/jb.185.19.5882-5890.2003.
PMID: 13129961

Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza
J Biol Chem. 2003 Dec 12;278(50):49763-72. doi: 10.1074/jbc.M308775200. Epub 2003 Sep 30.
PMID: 14522970

Proteins in this family with 3D-structure
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