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The Type IX secretion system membrane protein (PorP/SprF) Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment | Pfam page | TC-DB page

SprP is associated with the outer membrane of Cytophaga hutchinsonii. It is suggested that SprP is involved in protein secretion, a hypothesis made due to its sequence similarity with PorP that is responsible for the secretion of gingipain protease virulence factors in Porphyromonas gingivalis type IX secretion system (T9SS) and SprF that is crucial for the delivery of the gliding motility machinery components to the cell surface.

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Literature references

Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System
PLoS Pathog. 2016 Aug 10;12(8):e1005820. doi: 10.1371/journal.ppat.1005820. eCollection 2016 Aug.
PMID: 27509186

Deletion of the Cytophaga hutchinsonii type IX secretion system gene sprP results in defects in gliding motility and cellulose utilization
Appl Microbiol Biotechnol. 2014 Jan;98(2):763-75. doi: 10.1007/s00253-013-5355-2. Epub 2013 Nov 21.
PMID: 24257839

Elixir UTH dib compgen