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The Carbapenem resistance-associated outer membrane protein (carO) Family [Function: Specific diffusion channels] Seed alignment | Full alignment | TC-DB page

This family contains outer membrane proteins responsible for carbapenem resistance in the Moraxellaceae family of Gamma-Proteobacteria. Resistance to both imipenem and meropenem in multidrug-resistant clinical strains of Acinetobacter baumannii is associated with the loss of a heat-modifiable 29 kDa outer membrane protein, designated carO, which was the first identified member of the family and its structure revealed an 8-stranded monomeric ß-barrel. CarO (carbapenem-associated outer membrane protein) from Acinetobacter baumannii is a small OM protein that has been implicated in the uptake of ornithine and carbapenem antibiotics. The crystal structure of CarO showed a monomeric eight-stranded barrel lacking an open channel.

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Literature references

The Outer Membrane Proteins OmpA, CarO, and OprD of Acinetobacter baumannii Confer a Two-Pronged Defense in Facilitating Its Success as a Potent Human Pathogen
Front Microbiol. 2020 Oct 6;11:589234. doi: 10.3389/fmicb.2020.589234. eCollection 2020.
PMID: 33123117

Decreased carO gene expression and OXA-type carbapenemases among extensively drug-resistant Acinetobacter baumannii strains isolated from burn patients in Tehran, Iran
Acta Microbiol Immunol Hung. 2020 Apr 24. doi: 10.1556/030.2020.01138. Online ahead of print.
PMID: 32365048

Analysis of the Extracellular Proteome of Colistin-Resistant Korean Acinetobacter baumannii Strains
ACS Omega. 2020 Mar 11;5(11):5713-5720. doi: 10.1021/acsomega.9b03723. eCollection 2020 Mar 24.
PMID: 32226849

Mutation of CarO participates in drug resistance in imipenem-resistant Acinetobacter baumannii
J Clin Lab Anal. 2019 Oct;33(8):e22976. doi: 10.1002/jcla.22976. Epub 2019 Jul 18.
PMID: 31318107

Prevalence and Mechanisms of Carbapenem Resistance Among Acinetobacter baumannii Clinical Isolates in Egypt
Microb Drug Resist. 2019 May;25(4):480-488. doi: 10.1089/mdr.2018.0141. Epub 2018 Nov 3.
PMID: 30394846

ISAba36 inserted into the outer membrane protein gene carO and associated with the carbapenemase gene bla(OXA-24-like) in Acinetobacter baumannii
J Glob Antimicrob Resist. 2018 Dec;15:107-108. doi: 10.1016/j.jgar.2018.08.020. Epub 2018 Aug 29.
PMID: 30172044

Molecular characterization and clonal dynamics of nosocomial blaOXA-23 producing XDR Acinetobacter baumannii
PLoS One. 2018 Jun 11;13(6):e0198643. doi: 10.1371/journal.pone.0198643. eCollection 2018.
PMID: 29889876

The Acinetobacter Outer Membrane Contains Multiple Specific Channels for Carbapenem ß-Lactams as Revealed by Kinetic Characterization Analyses of Imipenem Permeation into Acinetobacter baylyi Cells
Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01737-16. doi: 10.1128/AAC.01737-16. Print 2017 Mar.
PMID: 28069648

Virulence characteristics of Acinetobacter baumannii clinical isolates vary with the expression levels of omps
J Med Microbiol. 2017 Feb;66(2):203-212. doi: 10.1099/jmm.0.000394. Epub 2017 Mar 7.
PMID: 27902395

In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
Nat Commun. 2016 Nov 11;7:13414. doi: 10.1038/ncomms13414.
PMID: 27834373

Resistant mechanisms and molecular epidemiology of imipenem-resistant Acinetobacter baumannii
Mol Med Rep. 2016 Sep;14(3):2483-8. doi: 10.3892/mmr.2016.5538. Epub 2016 Jul 22.
PMID: 27485638

[A study of outer membrane protein and molecular epidemiology of carbapenem-resistant Acinetobacter baumannii]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):611-5. doi: 10.3760/cma.j.issn.2095-4352.2015.07.014.
PMID: 26138426

[Analysis of the mechanism of drug resistance of VIM-2-type metallo-ß-lactamase-producing Acineto- bacter baumannii isolated from burn patients and its homology]
Zhonghua Shao Shang Za Zhi. 2015 Jun;31(3):205-10.
PMID: 26564568

Small-Molecule Transport by CarO, an Abundant Eight-Stranded ß-Barrel Outer Membrane Protein from Acinetobacter baumannii
J Mol Biol. 2015 Jul 17;427(14):2329-39. doi: 10.1016/j.jmb.2015.03.016. Epub 2015 Apr 3.
PMID: 25846137

Carbapenem-resistant Acinetobacter baumannii from Serbia: revision of CarO classification
PLoS One. 2015 Mar 30;10(3):e0122793. doi: 10.1371/journal.pone.0122793. eCollection 2015.
PMID: 25822626

An outbreak of blaOXA-51-like- and blaOXA-66-positive Acinetobacter baumannii ST208 in the emergency intensive care unit
J Med Microbiol. 2014 Nov;63(Pt 11):1517-1523. doi: 10.1099/jmm.0.077503-0. Epub 2014 Aug 20.
PMID: 25142965

Triclosan can select for an AdeIJK-overexpressing mutant of Acinetobacter baumannii ATCC 17978 that displays reduced susceptibility to multiple antibiotics
Antimicrob Agents Chemother. 2014 Nov;58(11):6424-31. doi: 10.1128/AAC.03074-14. Epub 2014 Aug 18.
PMID: 25136007

Incubation temperature, osmolarity, and salicylate affect the expression of resistance-nodulation-division efflux pumps and outer membrane porins in Acinetobacter baumannii ATCC19606T
FEMS Microbiol Lett. 2014 Aug;357(2):136-43. doi: 10.1111/1574-6968.12530. Epub 2014 Jul 25.
PMID: 25039371

Channel formation by CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii
Antimicrob Agents Chemother. 2005 Dec;49(12):4876-83. doi: 10.1128/AAC.49.12.4876-4883.2005.
PMID: 16304148

Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins
Antimicrob Agents Chemother. 2005 Apr;49(4):1432-40. doi: 10.1128/AAC.49.4.1432-1440.2005.
PMID: 15793123

Proteins in this family with 3D-structure
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